2-AG (2-Arachidonoylglycerol) is an endocannabinoid that plays a part in the endocannabinoid system (ECS). With the ECS as part of the nervous system, 2-AG is a neurotransmitter that modulates the cells that it encounters. These instructions happen on a certain rhythm conducted by the body’s internal clock. For example, research has shown that during the afternoon is when levels of 2-AG naturally peak; around when it’s time to relax and recharge as the day falls into night.

This particular endocannabinoid is the primary agonist for CB2 receptors, which predominantly influences the immune system.

While 2-AG modulates our immunity, it also affects our CB1 receptors in which it plays a part in regulating mood, sleep, metabolism, pain, bone health, reproduction, memory, movement, and neuroprotection.

CBD can help increase the levels of 2-AG by preventing it from being broken down, while it also affects the response of CB1 receptors. Because 2-AG works under the body’s circadian rhythm, sleep is important in keeping the circulating levels regulated.

Since CBD helps in modulating CB1 receptors, it can help a person balance their circadian rhythm which will balance their sleep schedule. Thus keeping their 2-AG levels in check!

Sources:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399498/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301686/#sd2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954479/

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