Cytochrome P450 & Drugs that May Interact with CBD

Cytochrome P450 & Drugs that May Interact with CBD
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We would not be living without our livers. Our livers detoxify our body from anything that could potentially harm us and actually has its own cleansing system called the cytochrome p450 enzymes system. According to research the system contains more than 50 enzymes that process and eliminate toxins from our bodies. There are drugs that may interact with CBD.

Why is this something to bring up about in relations to CBD? As most of us are coming to understand, CBD has the potential to effectively treat various illnesses and diseases by manipulating the endocannabinoid system with no “dirty” side effects. However, there may be one side effects to keep in mind, which is the inhibition of the cytochrome p450 enzyme system.

By inhibiting the cytochrome p450 system, it may lead to an overall increase in the processing of the other drugs in your system. Thus the other drugs may not metabolize as they should. This can lead to higher levels of the other medication in your system at one time, which can cause unwanted side effects and even overdose. so, if you’re taking a medication that could be affected by cannabidiol, you may need a dose adjustment in order to take both medications safely.

Medications that are known to use the cytochrome p450 enzyme system

Here is a list of medications that are known to use the cytochrome p450 enzyme system, according to the Indiana University Department of Medicine:

  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV antivirals
  • Immune modulators
  • Benzodiazepines
  • Anti-arrythmics
  • Antibiotics
  • Anti-psychotics
  • Anti-depressants
  • Anti-epileptics
  • Beta blockers
  • PPIs
  • NSAIDS
  • Angiotension II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

Before you begin to worry, not every medication in each of the categories listed will cause an interaction. But, be aware that this list does not necessarily contain every medication that could be affected by Cannabidiol. While it’s true that taking CBD by itself has not been shown to cause any unwanted side effects, it may increase the chances of experiencing side effects from other medications you might be taking at the same time.

If you feel worried that your cytochrome p450 enzyme system may not be functioning properly, doctors can test the system to ensure that medications you are you take are metabolizing as expected. Before starting CBD, especially if you’re on other medications, it is wise to consult your doctor or physician first.

Sources:

https://www.ncbi.nlm.nih.gov/m/pubmed/26651971/

http://medicine.iupui.edu/clinpharm/ddis/main-table/

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